The Effect of Glutamine Supplementation on Exercise-Induced Oxidative Stress

The shift in balance between oxidant/antioxidant in favor of oxidants is termed oxidative stress. Physical exercise may increase accumulation of free radicals and induce oxidative stress. The aim of this study was to evaluate effect of 7 day glutamine supplementation on exercise-induced oxidative stress. Nineteen healthy, nonsmoking, young men were recruited to participate in this study. Participants were randomized in a double-blind placebo-controlled fashion into 2 groups: Glutamine (G group) (n = 9) and placebo (P group) (n = 10). Subjects consumed daily either placebo (1.5 g/kg glutamine + 250ml water + 15g sweetener) or glutamine (250ml water + 15g sweetener) for 7 days. Then, Participants ran 14 km. Blood samples were taken before supplementation, before exercise, immediately, and 1h after exercise. TAC significantly increased immediately after exercise compared with preexercise just in G group (P<0.05). There was significant GHS increasein G group after supplementation, immediately, and 1h after exercise, but just 1h after exercise in P group compared with baseline(P<0.05). MDA-TBARS significantly increased 1h after exercise compared with preexercise just in P group (P<0.05). It seems 7day glutamine supplementation has been able to affectoxidative stress markers via possibly effect on antioxidant agents.